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Many proteins that function in this compartment are dependent on thiol-containing cysteine residues that are prone to oxidative damage by reactive oxygen species (ROS) produced during normal aerobic metabolism

doi: 10.1016/j.jot.2020.09.006 97 LuoHZhangR

Its biological activity is primarily driven by the reactive thiol (-SH) group on the cysteine residue, which enables participation in electron transfer and conjugation reactions

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1983), Glu/Gln dropped noticeably during early reperfusion (3 h) and gradually increased over 24 h reperfusion in the hippocampus and cortex, but not the cerebellum