Zentronukleäre Myopathie (IMGD) - Deutsche Dogge Mischling Inflammatory Myopathy (CDMC) is a

Inflammatory Myopathy (CDMC) is a disease that affects cerebellum (the area of brain that controls coordination and balance) and muscles

life-threatening disorder of weak and thin heart

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Mutation: LARGE1 gene

loperamide

Zentronukleäre Myopathie (IMGD) - Deutsche Dogge Mischling Inflammatory Myopathy (CDMC) is aCharacteristic signs of centronuclear myopathies include generalized muscle weakness, atrophy, predominance of type I fibres, and aberrant cell positioning of nuclei and mitochondria. In Great Danes generalized muscle atrophy, exercise intolerance, exercise induced tremor and muscle wasting characterize the disease. The disease typically starts before 10 months of age, is highly progressive, and most of the affected dogs are euthanized before 18