Thrombopathie - American Eskimo Dog Diversität D-Locus is responsible for coat

D-Locus is responsible for coat colour dilution

Three different alleles are described on K-Locus with following hierarchy: KB (dominant black) > kbr (brindle) > ky (normal)

Mutation: KCNJ10 gene

affected dogs remain ophthalmoscopically normal

and different mutations in the VWF gene are responsible for quantitative and qualitative vWF properties which are the basis for dividing vWD into vWD type I (partial absence of vWF)

Thrombopathie - American Eskimo Dog Diversität D-Locus is responsible for coatThrombopathia is an inherited platelet disorder. Affecteddogs have abnormal platelet function because they are not able to stick together properly and therefore cannot form a clot. Dogs exhibit typical signs of platelet defects including bleeding from snouts, gingival bleeding,and petechiation. Other symptoms include weakness and rear limb paralysis secondary tospinal cord hemorrhage. The platelet defect is characterized by impairedor absent platelet