D-Lokus (d3) CatCheck Laktatazidose

Laktatazidose

CDDY/IVDD was associated with FGF4 gene insertion on chromosome 12

inflammation (cholecystitis) and possible rupture of the gallbladder

severe mental retardation

that causes a symmetric bilateral necrotising myelopathy with tissue softening in the ventral and dorsal white matter

D-Lokus (d3) CatCheck LaktatazidoseD Locus is responsible for coat colour dilution. Known mutations of the MLPH gene (melanophilin) are responsible for most cases of diluted colours. MLPH gene encodes a protein melanophilin, a key component in the hair and skin pigment formation. A mutation in the gene causes the improper distribution of melanosomes and coat colour dilution. It has an effect on the formation of black eumelanin as well as red yellow pheomelanin, though in lesser extent.